As you know, most of us use fairly thick patches with our roundballs when we are loading a rifle.
Patches in the .018 (eighteen thousandths) of an inch are common.
For a muzzleloading pistol, things are different.
The smaller powder charge along with the difficulty in starting a patched ball with a thick patch has convinced me that the thick patch is not needed with a pistol. It can cause more trouble than it's worth.
I agree that the patch thickness should be about the same as the rifling groove depth.
Dixie Gunworks says the rifling grooves in your pistol are .008 deep.
That would work nicely with a patch that is .010 thick.
A .010 thick patch would seal the barrel in your .45 if you were using a .440 diameter ball.
As you know, your flintlock will need real black powder. The substitutes won't work well by themselves for priming or for the main powder charge.
Although the rule of thumb says you need 3Fg powder, if all you can get is 2Fg powder it will still work. It will give you slightly less velocity and it will also make more fouling but, it will work.
As for 4F powder, forget it.
The small difference in ignition speed between it and the courser powders is too small to be sensed and the powder charge to prime the pan is so small, one pound of 4F will last you several lifetimes. :grin:
Have fun.