The breech or barrel plug at the rear is not meant to be removed.
When the barrel was made, the plug was screwed in place with a great amount of torque.
To further strengthen the breech, CVA barrels use a nipple drum that screws into the side of the breech plug's threaded area, effectively pinning the breech plug in place.
Don't try to remove either the side drum or the breech plug from your guns barrel.
As for the screw in the end of the drum, it should unscrew if the nipple is not installed.
Many of these small screws become locked in place because the end of the screw threads becomes damaged by the nipple threads when it is installed.
Also, it is fairly common for the drum screw threads to become rusted in place.
This does not create a real safety hazard because basically the screws threads are over-designed for the pressure loads they must withstand.
Many people don't bother with trying to remove the drum screw.
The vent hole that was drilled thru the drum and is now plugged by the screw can be cleaned if you can find some old fashioned pipe cleaners.
The kind of pipe cleaners smokers use to clean their pipe stems.
These pipe cleaners are sometimes available at a drug store or at a store or shop that sells tobacco.
To use the pipe cleaner, remove the nipple and bend the end of the cleaner so it will start into the flame channel hole at the bottom of the nipple threads.
Wet the cleaner with water and snake it into the flame channel. Rotating it a bit and pushing it will allow it to work down thru the hole and clean it out.