I say the best thing for any shooter is to have a selection of powder. I've tried 1Fg, 1 1/2 Fg, 2Fg, 3Fg, and 4Fg, mainly in Goex Red or OE, although I've tried Swiss and Shutzen, as well as most blackpowder substitutes.
Everyone has their preference. I always end up coming back to 1 Fg, and that is mostly what I've bought the past few years. They all work. The cleanliness thing is mostly overblown. The finer the powder, the higher the pressure it produces with the same volume. I don't consider 4 Fg dangerous, but 60 grains of 4 Fg is going to produce higher pressure than 100 grains of 1 Fg. Right or wrong, that's just the way it is. The barrels on most of our rifles are thick, and with a PRB, pressure really don't ever get that high. I think the highest test I ever saw was with 3 Fg with a hefty charge, and it was only up around 15,000 PSI. I have equipment to test pressures, but it will not work on an octagon barrel. One of these days I'll test it out on one of my round barrel shotguns.