I had same questions regarding size of bore. I built a flintlock for Alaska hunting in .58 roundball with a 1-66 twist. I use 120 gr. of ffg and didn't consider myself undergunned.
I took the flinter to South Africa hunting plains game and was fortunate to get impala, kudu, waterbuck, and wildebeeste with it using 120 grains of South African powder that resembled fffg, and shot to same point of impact as my ffg load.
After seeing cape buffalo up close and personal, I think the 10 bore would be a good starting point for them. That said, I've been fussing with this .58 Getz barrel with 1-48 twist and scheming on a good conical load. The cape buffalo have ribs that actually overlap, and they are physically tough hombres besides being well-protected from an anatomical perspective.
The PH that was with me had serious reservations about me using the flinter at the start of the hunt. They don't see many flint shooters there!. After the first clatch trying to shoot at the impala, he and my wife were quite anxious. I knapped the flint, re-primed, and took the shot again, with successful outcome. The tracker/skinner was very impressed with the power of the .58 roundball on the impala. Didn't get complete penetration at 80 meters.
The kudu and wildebeeste were toaken with broadside shots at about 75 meters. Neither wasd complete penetration and both were able to make it between 150-200 meters following loss of their heart and both lungs. These guys are tough!
I took the waterbuck next to the Limpopo River, where if it took off, it would have been into Botswana. In this instance, I was able to take a 50 meter shot from the PH's tripod, and took a neck shot. I was fortunate, and the waterbuck dropped in it's tracks. The PH said he'd never seen one dropped so quickly. They were in rut, and the ball stopped just inside the hide on the opposite side of the neck after severing the spinal column and spinal cord.
After that series of events, the PH had gained confidence in the power of the .58, but I still have serious reservations about using the caliber for cape buffalo. Bigger may be better, and not just to .62! That said, I firmly believe the .62 to be sufficient for any North American critters using patched round ball.
Maybe with conical it would serve for Cape buffalo?? There's many good accounts from the old South African hunters that suggest having 8 bores + is best.
Stay tuned, as I hope to try it in 2007