I've done my best to wear out my Crockett over the years, but shooting snowshoe hare rather than squirrels. Because of the more open shots in some cases, I've always been intent on what it would do beyond 25 yards, as well as closer. My "hunting" range limit is more like 35 yards, even if I range test it all the way out to 50.
The day the Crockett arrived I load tested with 20 grains of 3f Goex, but verified against the same amount of Pyrodex P since I shoot that too. Next step was to sight it in, and I did that at 25 yards, putting the load about 1-2" low at 50 and not even an inch low at 35, while so little above the sights inside 25 that I couldn't measure it.
But game shooting experience has led to changes. I quickly discovered that 20 grains was waaaay too much in terms of impact damage. Fine on heads, but if you dropped down even a little it practically blew the rabbits in half. Worse than a 22 Mag hollow point, if you can imagine.
Started cutting charges lower and lower, seeking terminal performance on the order of 22LR. I'm down to 10 grains now, and without chronographing I'm still pretty sure I'm at or below 22LR velocities. Still have to be really careful about ball placement simply due to the larger size of the ball. It's kind of like hitting them with an already fully-expanded 22HP.
But through all that, I've never touched the sights again. It's still right on at 25, but 2-3" low at 50 while about an inch low at 35, with no changes inside 25 yards.
Good enuff for me. If I spot a snowshoe out at 35 to 50 and can find a good rest, I simply adjust my hold up a little. It's plenty accurate for head shots out at that range, but I'm mostly not.