Rules differ on many ranges. At NMLRA events, and shoots that use those same rules, you are NOT allowed to prime the gun until you are on the firing line, with the muzzle pointed down range. The rules require the gun be loaded BEHIND the firing line- usually at a bench provided for that purpose.
So, check the rules. I think you lose a lot of pressure/velocity opening the vent up enough to self prime- particularly if you are using FFg. If you are using FFFg, its much less a problem, because the vent hole does not have to be enlarged as much.
If you do open it up to self-prime, you can comply with the rules at the ranges that restrict priming by putting a toothpick into the vent, before loading the powder, patch and Ball. Then, when you are on the firing line, with the barrel pointed down range, you can remove the toothpick, and give the gun a slap, or whack of the butt of your hand on the off-side. That should make some of the powder in the barrel exit the vent into your pan.
Because You can't control the amount of powder that flows from the main charge into the pan, priming either before or after loading the powder patch and ball into the barrel, The Accuracy of your gun is affected adversely. A few granules of powder, in a large caliber musket( .75), one way or another, is not going to significantly change the POI of any projectile you shoot.
Without rifling, accuracy is " Minute of plate!" Some members here work very hard on their loads, and their shooting skills, and can shoot very small groups even out at 100 yds with a smoothbore. But, these same members will also shoot much smaller groups with a rifle in their hands. With the smaller caliber rifle- .50 caliber is what you are using---- changes in powder charges do move the POI. I shoot a .50, and off a bench rest, I can easily see the differences.
However, what any of us call " Accuracy" is very personal, and I gather that many people here think " minute of 6" plate" at 50 yards is all they require. If your shots are going to be limited to that short range, then I don't think self-priming is going to spoil your groups, using that standard of measurement. :thumbsup: