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I don't have a Lyman pistol (yet) but never push my other .50 pistols past 45 grains. Around 40 is pretty much optimal in my CVA pistols. As for patch, I don't hang up on that too much. I shoot thin patches (never measured them) and cut at the muzzle with .490 balls. My accuracy is fine at the hunting distances I use them for and loading is very easy.
 

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