Hodgdons site
http://www.hodgdon.com/pyrodex-pellets.html
gives the following proceedure for using their 30 grain pellets in a Cap and ball Pistol:
"Position unloaded revolver with barrel in vertical upright position, preferably in a loading stand.
Place revolver hammer in half-cock position.
With muzzle of revolver barrel away from body, rotate cylinder and align an empty chamber in cylinder with barrel and drop one (1) Pyrodex Pistol Pellet down barrel into empty chamber.
Rotate cylinder to next empty chamber and repeat step 3 until five (5) chambers are loaded. (WARNING) it is recommended as a safety precaution that only five (5) chambers be loaded, leaving empty chamber for the hammer to rest on when the remaining chambers are loaded.
With five chambers now loaded with Pellets, rotate cylinder and place a .44 or .45 caliber Ox-Yoke Wonder Wad® (or equivalent felt wad) in each chamber, seating each wad with revolver loading lever on top of Pellet.
Next, rotate cylinder and place correct size 44 or 45 caliber pure lead round ball in each chamber, seating each ball with loading lever on top of felt wad.
WARNING: Be certain that no air space exists between the projectile (ball) and Pellet. If an air space exists, the projectile becomes an obstruction in the chamber, which upon firing the revolver, may cause personal injury or death to the user or bystander, as well as damage to the firearm.
With revolver barrel pointed in a safe direction, rotate cylinder and insert proper size percussion cap on each of the nipples of the loaded chambers. Revolver is now ready to be fired. Aim firearm in safe direction, place hammer in full cock position and fire.
http://www.hodgdon.com/ml-warning.html
I think that if your getting them for free and you have a steel frame .44, they might be OK but I consider a 30 grain powder load to be a bit excessive for use in any brass frame pistol.