Practiced shooters would say the distance is helpful in one regard. Taking and returning fire at 10 yards is very different from a hundred.
Thats taking the comment somewhat out of context, it was a reply to someone mentioning "plugging in the numbers" which in most longer distance shooting and iron sights are used is irrelevant. Yes, theres some drop to account for, though not as much as most assume. Actually doing it is the best way to have successful results. I have absolutely zero idea what drop figures are for any handgun i shoot regularly at distances from 10 yards to 300+, and any point in between, nor is it really useful in the way I use the sights, but can generally hit or be very close first round.
Most that actually shoot 100 yards find that if they aim with the sight even across the top (normal sight picture) as most do for closer distance, then a shoulder level hold keeps the hits in a usable area of the intended target, if one is talking defensive use. Using a better sight hold, such as letting a sliver of front sight sit above the rear and keeping the front sight/target relationship the same, will generally give better results. And that sliver is very small at 100. Hitting with a pistol at 100 yards isnt very difficult. Hitting rabbits and prairie dogs at 80-90 yards isnt very difficult with some practice and experience.
This brings us back to how we understand "practiced shooters" If they havent shot distance much, even 100 yards, its a new game. I know of very good trap shooters that were horrified when they first shot sporting clays because of their poor scores. Doing one similar thing doesnt infer capabilities with another thing one hasnt done much or at all. After doing it a bit, scores went up dramatically, but theres somewhat of a learning curve.