Kinda yes / kinda no
The barrel screws off but as best I can tell you actually load it with the barrel on.
Perhaps someone who’s shot theirs can confirm?
The pistol referred to is the currently sold Pedersoli screw barrel pistol where the frame has a pocket where powder and ball is loaded and then the barrel is screwed onto the frame using a special supplied tool. When fully cocked, the trigger flips out from the frame. The Classic Arms New Orleans Ace pistol that your selling is a muzzleloader. What's nice about the New Orleans Ace pistol is that it is super easy to clean as the barrel is simply screwed off the frame.
Pedersoli Screw Barrel Pistol