If one were to only use the 110 grain soft lead concial in a 32 caliber, then, yes, at short distances it would reasonably kill deer. But, that is a rare oddity and I doubt many would consider it in a traditional rifle. 3 and half decades ago a few squirrels fell to that combo, but then roundballs made more sense for small game and the slugs were put away. Still, I can see how it could be successful in the right hands. I've not kept up with the inlines since giving my last one away to a brother. Didn't know they were making them less than 45 caliber for 35 caliber pistol bullets at super velocity, but it wouldn't surprise me. I would rather use a good side lock and open sights as long as possible, though.