Overall I find small calibers to be more "sensitive" to slight variations in loading method as well as component mixes. The amount of pressure you put on the rod once the ball is seated sure affects mine, both the Crockett and my 30 cal (.290 ball). Less so with my 36 cal. Can't put a measure on it, but it requires seating pressure just short of feeling the powder crunch.
Mine also seems to prefer a light dose of grease type lube, whether a blend of deer tallow and olive oil or TOW's mink tallow. I never had much luck with the Hoppe's, but I could well have been using too much or too little, or it might have had something to do with my particular patch/ball combo (.311 ball from a LEE mold and .018ish ticking). My combo is tight enough to need a short starter and a fair whack on it to get the ball moving.
Biggest thing is to try different things, but only make on change at a time as you experiment. Dropping the charge below 20 had a bigger impact on my accuracy than everything else put together, but dinks with lube/patch/ball/seating all helped refine it after I found the right powder charge.