I did a semi-scientific study on out-of-round lead projectiles 30 years ago. I had a Lyman mold that was .003 Out of round. Marked the sprue with a sharpie, then proceeded to load them exactly the same, 90 degree orientations, random orientations, etc. even did a blind test with someone loading the ball for me. Not one damn bit of difference in group size, group location, etc. I believe the soft lead projectile deforms easily and as long as the base isn’t mutilated, it doesn’t make a difference. It’s your eyes by the way, try opening or closing the opposite eye. If you aren’t consistent, you’ll get two different sight pictures and two groups. Been there, done that.