As others have said a well placed shot from a .50 cal. ball will drop a deer in its tracks and so will a .22 bullet. Have you ever wondered why the ML,s made for the Civil War were .58 cal.? The truth is it does a better job on marginal shots!No hesitation at all with a 50 or 45 cal. LRB. Keep a well placed shot at reasonable range (<75 yards) and you will have a dead deer.