My conical experience has been with Pedersoli .54's. A Frontier and a Rocky Mountain Hawken both with 1-65 twist. These guns have square bottomed rifling that, compared to round bottom roundball barrels, is relatively shallow. I had no luck with solid base bullets like the TC Hunter. I don't think the bases obturated to fill the rifling enough. But the hollow based Buffalo Bullets, Ballets, and the big Hornady Great Plains shot with excellent results. I shot numerous deer with them.
Here's a Great Plains bullet shot into a big bodied buck at 90 yards. The load was 90 grains of 2F. It broke through rib on the way in, tore the heart in two, went through rib on the way out, but stopped just under the hide.
I have a new bullet next to the shot one for comparison. Once the shot bullet was all cleaned up and weighed, it had only lost 1 grain of weight compared to the spec weight...and maybe it was one grain lighter to begin with. I don't know how one could ask anything more from a hunting projectile.
Here's the heart as I found it when gutting.
The buck was tooth section aged in a lab at 7 1/2 years old and was a little over 200 pounds dressed. The first picture shows just how big of a body he had when alive and well.
All that said, with many deer shot with those two guns with both a patched .530 RB over the same 90 grains or the big heavy bullet, there was probably no average difference in how they killed. As a comparison on similarily body sized animals I shot this buck with a .530 RB at 65+ yards on the move and he went all of 25 yards before going down. The blood on the ground in the 25 yards was nothing short of awesome. The ball was in and out breaking ribs on both sides and going off into the woods somewhere.
The biggest differences were that the recoil with the GP bullet was substantially more and I had about 6" more drop at 100 yards. And for what? So I've quit using the big bullets and now just use the PRB. It's everything I need.